Diagnosis, treatment of transitional cell carcinoma (TCC) in dogs
Jul 01, 2008
Malignant tumors of the lower urinary tract include transitional cell carcinoma, squamous-cell carcinoma, adenocarcinoma, leiomyosarcoma, fibrosarcoma, hemangiosarcoma and rhabdomyosarcoma.
EtiologyThere appear to be both genetic and environmental risk factors for the development of TCC in dogs. In humans, cigarette smoking, exposure to chemicals, use of select medications and chronic inflammatory conditions of the bladder have been associated with an increased risk of bladder tumors.
Previous studies have found that dogs exposed to insecticidal dips, live near marshes or are overweight are at higher risk for the development of bladder tumors. Prior use of Cytoxan has been suggested as a risk factor. Two recent studies evaluated exposure to herbicides and topical flea and tick pesticides as possible risk factors in Scotties (Glickman 2004, Raghaven 2004). The conclusions were that the use of the topical flea and tick medications currently available did not increase the risk of TCC, but exposure to phenoxy herbicides did.