The mineral composition of uroliths in dogs has varied in the last three decades. In this article, we evaluate canine uroliths
submitted to the Minnesota Urolith Center to determine whether trends during 2011 were different from previous years. We then
look at what this information might mean for our patients.
Composition comparison over three decades
Overall, data indicate minimal variation in calcium oxalate urolith percentages compared with the recent past (Figure 1).
But, over time, a shift in composition has occurred.
In 1981, calcium oxalate was detected in only 5 percent of canine uroliths submitted to the Minnesota Urolith Center, whereas
struvite was detected in 78 percent of canine uroliths. At that time, canine calcium oxalate uroliths were considered to be
rare. During subsequent years, canine calcium oxalate uroliths were thought to be associated with trends similar to those
that we have documented in cats. As with cats, during the past 30 years, there has been a substantial increase in calcium
oxalate uroliths (42 percent) and a substantial decrease in struvite (also called magnesium ammonium phosphate) uroliths (39
percent) (see Table 1 and Figures 1–4).
Possible causes of this decline in the frequency of naturally occurring struvite uroliths and a reciprocal increase in calcium
oxalate uroliths include:
1. Widespread use of a calculolytic food designed to dissolve sterile struvite uroliths
2. Widespread use of maintenance and prevention foods modified to minimize struvite crystalluria—some dietary risk factors
that decrease the risk of struvite uroliths increase the risk of calcium oxalate uroliths
3. Inconsistent follow-up evaluation of efficacy of dietary management protocols by urinalysis and radiography.
Likewise, the probability that > 95 percent of the canine struvite uroliths submitted to our center were induced by microbes
that produced urease-producing enzymes, while < 95 percent of the feline uroliths were not associated with urease-positive
microbes, is problematic. A hypothesis that might explain, at least in part, the trend toward increased calcium oxalate occurrence
in both groups is the treatment of canine infection-induced uroliths with an appropriate diet and antimicrobial drugs and
the treatment of sterile feline uroliths with an appropriate diet.
Being aware that infection-induced struvite is a major mineral type in dogs and sterile struvite is a predominate mineral
type in cats—and that the cause of sterile struvite and infection-induced struvite is different—is helpful when formulating
An appropriate antimicrobial agent and an appropriate diet (e.g., Prescription Diet s/d Canine canned—Hill's Pet Nutrition)
are required to consistently induce dissolution of infection-induced uroliths in dogs, while preventing urinary tract infections
is essential to minimize the recurrence of infection-induced uroliths. A special diet is not necessary. Consumption of an
appropriate diet is usually effective in dissolving and minimizing the recurrence of sterile struvite uroliths.