COLUMBIA, MO — A group of researchers is exploring ways to diagnose and treat osteoarthritis in the earliest stages, before irreversible
damage is done to joints.
James "Jimi" Cook, DVM, PhD, is leading a group at the Comparative Orthopaedics Laboratory (COL) at the University of Missouri
Department of Veterinary Medicine in Columbia, Mo., in the effort. COL was founded in 1998 by Cook and Keith Kenter, MD. The
COL team is diverse and includes veterinarians, physicians, engineers, biochemists and pathologists.
"The goals of the COL are to find ways to promote joint health and better diagnose, treat and prevent joint disease in people
and animals," Dr. Cook says.
Osteoarthritis in animals and humans
Osteoarthritis is a chronic degenerative joint disease involving both soft and bony tissues. The causes include trauma, infectious
processes, congenital abnormalities or immune system responses. Osteoarthritis can affect dogs, cats, horses, birds, even guinea pigs. Some estimates place the incidence as high as 20 percent
in all cats over the age of 12 years and, in some dogs, especially the larger and rapidly growing breeds, the incidence of
osteoarthritis can approach 75 percent.
In humans, osteoarthritis is one of the leading causes of disability. More than 20 million people in the United States are
affected, and most adults over the age of 50 display some symptoms. It is projected that as the baby-boom generation ages,
the number of cases of osteoarthritis stands to increase dramatically.
Cook and his team realized that for all patients — animal and human — no treatment for osteoarthritis is anything more than
palliative because the diagnosis is usually made later in the course of the disease, after the patient has already been experiencing
significant pain in the joint. By that time, damage to the joint is usually irreversible.
"In theory, and based on basic science, there is a stage of OA that is reversible," Cook says. "We decided to say, 'Is there
any way through all the technology and methodology we have available we can diagnose OA in the reversible stage?'"
Because osteoarthritic changes manifest in dogs within the span of a few weeks, Cook and his team developed a three-month
study of 12 dogs they knew were statistically likely to develop osteoarthritis. Using clinical assessments, MRI and arthroscopic
examinations, and laboratory testing such as histology, biochemistry, and gene expression analysis, complete examinations
of the study animals were performed during weeks one, two, four, eight and 12.
Cook tells DVM Newsmagazine that changes in specific genes' expression occurred as soon as two weeks after the insult that would eventually result in
clinical signs and symptoms of osteoarthritis, even though at the time of gene expression measurement the animals were completely
"We find the abnormal gene expression at two weeks, then definitive MRI changes associated with osteoarthritis at eight weeks.
Then we go back to the two-week MRI to see if we can tease out changes that may be predictive of arthritis at those early
stages," Cook says.
The team's findings were confirmed by further tests on other groups of dogs, and the most recent testing of approximately
50 animals will be concluded by the end of this year.
"We have enough information that companies are interested to test drugs already. We're seeing if we can evaluate effectiveness
of drugs earlier in the process," Cook says. "We have a long way to go, but everything has been really positive so far."
Cook plans to apply for grants from the National Institutes of Health (NIH) to conduct further tests in animals and, eventually,
humans. He anticipates the entire research to take five to 10 years to complete.
Cook credits his team at the COL with the success of their work so far.