Suggested withdrawal times and threshold concentrations of therapeutic medications - DVM
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Suggested withdrawal times and threshold concentrations of therapeutic medications


DVM360 MAGAZINE

Detection of a therapeutic substance at concentrations higher than the reported threshold will result in sanctions, according to the Mid-Atlantic Uniform Medication and Testing Program. (LOD = level of detection.)

Untitled Document
Drug Dose/Route Withdrawal (no pre-race treatment within) Threshold
Acepromazine 0.05 mg/kg IV (single dose) 48 hours 10 ng/ml HEPS (applicable metabolite) in urine
Betamethasone 9 mg IA only—1 joint 7 days 10 pg/ml of plasma or serum
Butorphanol 0.1 mg/kg IV (single dose) 48 hours 300 ng/ml of total butorphanol in urine, or 2 ng/ml of free butorphanol in plasma
Clenbuterol 0.8 µg/kg PO twice daily 14 days 140 pg/ml of urine or LOD in plasma or serum
Dantrolene 500 mg PO 48 hours 100 pg/ml 5-hydroxydantrolene in plasma or serum
Detomidine 40 µg/kg single sublingual dose 72 hours LOD in plasma or 1 ng/ml of carboxydetomidine in urine
Dexamethasone 0.05 mg/kg IV, IM, PO 72 hours 5 pg/ml of plasma or serum
Diclofenac (topical) 5-in ribbon topically 48 hours 5 ng/ml of plasma or serum
DMSO PO, IV 48 hours 10 µg/ml of plasma or serum
Firocoxib 0.1 mg/kg PO daily for four days 14 days 20 ng/ml of plasma or serum
Flunixin 1.1 mg/kg IV single dose 24 hours 20 ng/ml of plasma or serum
Furosemide Maximum 500 mg IV single dose 4 hours 100 ng/ml of plasma or serum
Glycopyrrolate 1 mg IV single dose 48 hours 3 pg/ml of plasma or serum
Ketoprofen 2.2 mg/kg IV single dose 24 hours 10 ng/ml of plasma or serum
Lidocaine 200 mg SC 72 hours 20 pg/ml of total 30H-lidocaine in plasma
Mepivacaine 0.07 mg/kg SC single dose 72 hours 10 ng/ml of total hydroymepivacaine in urine or LOD in plasma
Methocarbamol   0.15 mg/kg single dose IV or 5 g orally 48 hours 1 ng/ml of plasma or serum
Methylprednisolone* (IA only) 100 mg—1 joint 21 days* 100 pg/ml in plasma or serum
Omeprazole 3.9 mg/kg PO single dose 24 hours 1 ng/ml of urine
Phenylbutazone (IV only) 2.2 mg/kg IV single dose 24 hours 2 µg/ml of plasma or serum
Prednisolone 1 mg/kg PO 48 hours 1 ng/ml plasma or serum
Procaine penicillin** IM Entry** 25 ng/ml of plasma
Triamcinolone acetonide 9 mg IA—1 joint 7 days 100 pg/ml of plasma or serum
Xylazine IV 48 hours 0.01 ng/mg of plasma or serum

*Methylprednisolone following intraarticular administration of 100 mg can be detected at 100 pg/ml for up to 21 days. Its use is therefore problematic.

**Mandatory six-hour surveillance of horse prior to post. Administration mush be reported to commission.

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Source: DVM360 MAGAZINE,
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