The pulmonary changes vary from diffuse congestion to necrosis of alveolar walls and hemorrhages. The spleen usually is enlarged
greatly. Focal necrosis and hemorrhages also are common in the liver, intestinal tract and lymph nodes. There are extensive
foci of coagulation necrosis in the adrenal glands. The meninges are commonly congested and are infiltrated by lymphocytes
and macrophages. There are occasional hemorrhages in the cerebral cortex, and microscopically, perivascular foci of macrophages
and lymphocytes are evident. Within these foci, there are necrotic and disintegrating neurons. With the fluorescent antibody
technique, virus can be demonstrated in virtually every tissue of the body. Infected cells are focal in distribution.
The determination of canine herpesvirus infection in puppies usually depends on the information obtained from clinical history
and physical examination.
Dr. Hoskins is owner of DocuTech Services. He is a diplomate of the American College of Veterinary Internal Medicine with
specialities in small animal pediatrics. He can be reached at (225) 955-3252, fax: (214) 242-2200, or e-mail: