Oral squamous cell carcinoma in cats - DVM
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Oral squamous cell carcinoma in cats
Tips for catching this invasive neoplasia as early as possible.


DVM360 MAGAZINE


Take-home advice

Although feline SCC is aggressive, excision without recurrence is possible in select cases. If an oral mass is suspected in any cat, dental radiographs and a deep biopsy are needed to confirm. All suspected and confirmed cases should be discussed with the owner, and immediate referral to a veterinary dental specialist should be considered. For a list of board-certified specialists, visit http://avdc.org/.

Dr. Beckman is acting president of the American Veterinary Dental Society and owns and operates a companion animal and referral dentistry and oral surgery practice in Punta Gorda, Fla. He sees referrals at Affiliated Veterinary Specialists in Orlando and at Georgia Veterinary Specialists in Atlanta, lectures internationally and operates the Veterinary Dental Education Center in Punta Gorda.

References

1. Withrow SJ, MacEwen EG. Cancer of the gastrointestinal tract. In: Small animal clinical oncology. 3rd ed. Philadelphia, Pa: Saunders, 2001;305.

2. Mantra-Marietta S, Matheissen D, Matus R, et al. Surgical management of oral neoplasia. In: Bojrab MJ, Tholen M, eds. Small animal oral medicine and surgery. Philadelphia, Pa: Lea & Fiber, 1990;108

3. Bregazzi VS, LaRue SM, Powers BE, et al. Response of feline squamous cell carcinoma to palliative radiation therapy. Vet Radiol Ultrasound 2001;42(1):77-79.

4. Fidel J, Lyons J, Tripp C, et al. Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. J Vet Intern Med 2011;25(3):504-510.

5. Wakshlag JJ, Peters-Kennedy J, Bushey JJ, et al. 5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats. Am J Vet Res 2011;72(10):1369-1377.

6. Bergkvist GT, Argyle DJ, Pang LY, et al. Studies on the inhibition of feline EGFR in squamous cell carcinoma: enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors. Cancer Biol Ther 2011;11(11):927-937.

7. Martin CK, Dirksen WP, Shu ST, et al. Characterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma. Oral Oncol 2012 Jan 20. [Epub ahead of print].

8. Tannehill-Gregg SH, Levine AL, Rosol TJ. Feline head and neck squamous cell carcinoma: a natural model for the human disease and development of a mouse model. Vet Comp Oncol 2006;4(2):84-97.

9. Nagata K, Selting KA, Cook CR, et al. 90Sr therapy for oral squamous cell carcinoma in two cats. Vet Radiol Ultrasound 2011;52(1):114-117.

10. Northrup NC, Selting KA, Rassnick KM, et al. Outcomes of cats with oral tumors treated with mandibulectomy: 42 cases. J Am Anim Hosp Assoc 2006;42(5):350-360.


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