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Furosemide facts and fiction
When it comes to the use of furosemide for treating EIPH, here's what we can all agree on.


Administering a competitive edge

Hinchcliff was also the lead researcher on a groundbreaking study released in 2009 looking at the effects of furosemide.6 In this uniformly accepted, well-designed study, 155 South African racehorses from 40 different stables were raced in a controlled environment. The distance, track surface, jockey influences and as many other factors as possible were kept the same. Horses were raced once after being given furosemide, and then, one week later, the same horses were raced after receiving a placebo of saline solution.

After the race (roughly 42 minutes later), the horses were returned to the parade ring and untacked, and a tracheobronchoscopic examination was performed. Hinchcliff was able to show that 57 percent of the horses running after furosemide administration demonstrated EIPH, while 79 percent of the same horses showed evidence of bleeding after saline treatment. The degree of severity of cases of EIPH was substantially reduced with furosemide treatment as well. No cases of severe (grade three or four) bleeding were noted with furosemide treatment, and all horses were judged to be grade two or less (the levels thought to have minimal to no effect on performance). This study finally confirmed what many other studies and countless horsemen believed: Furosemide reduces the severity and influences of EIPH in performance horses.

"There is ample scientific evidence that furosemide decreases the severity of EIPH in horses," says Warwick Bayly, BVSc, MS, PhD, DACVIM, of the College of Veterinary Medicine at Washington State University. "In the long term, reducing the severity of EIPH bouts is beneficial to lung health, as the presence of blood in the lungs has been shown to induce permanent changes in their tissue structure."

In support of veterinary treatment in the best interest of the horse, the American Association of Equine Practitioners (AAEP) maintains that "horses that experience EIPH should receive appropriate veterinary care; furosemide is currently the most effective therapeutic medication available for the treatment of EIPH; and increased scientific research regarding EIPH will provide improved treatment options and the greatest benefit to the health and welfare of the horse."7

Furosemide is a loop diuretic and causes increased excretion of water in the urine. One consequence of increased water loss is decreased blood pressure, which helps reduce bleeding associated with EIPH. Exactly how much water loss do we see after furosemide administration? Many values have been tossed around in this diuretic debate—from 20 pounds to 100 pounds. Hinchcliff's study definitively showed that furosemide use was associated with 27.9 pounds of water loss compared with 11.9 pounds lost when racing after receiving saline solution.6 So horses lost an additional 16 pounds when treated with furosemide, which can give them a competitive advantage.

Another study by Hinchcliff's group specifically looked at the issue of furosemide and its effect on racing performance in horses in the United States and Canada.8 This study looked at the race records of more than 22,000 horses. They learned that 74.2 percent of these athletes competed on furosemide, and those that did "raced faster, earned more money, and were more likely to win or finish in the top three positions than horses that did not." This study estimated that in a 6-furlong race, a horse on furosemide would have a 3 to 5.5 length advantage. It is not known if the "winning edge" was due to a disproportionate loss of weight or an increase in air flow because of the absence of blood in the airways. Either way, this and other similar studies led to the third unchallenged scientific fact in this debate—furosemide use is strongly associated with improved performance in racehorses.

Rehashing the genetics debate

Some veterinarians, researchers, trainers and owners have stated that furosemide is not performance-"enhancing" but rather performance-"restoring." This drug does not make horses run any faster than they normally could, they argue. But it allows horses to perform at their normal physiological level, free from the effects of blood in their airways. If it is all about a level playing field, then furosemide just returns horses to normal, they contend.

Furosemide opponents counter that the field was never supposed to be level in the first place. Genetically superior horses that do not bleed and do not need furosemide should have an advantage over lesser-quality horses.

Genetics have been dragged into this debate in other ways as well. Critics of the use of furosemide to prevent or treat EIPH in racehorses think that its use is weakening the thoroughbred breed, since horses that race on furosemide and win then move to the breeding shed. There they possibly pass this propensity for EIPH and a need for drug treatment on to future generations of racehorses.

Whether EIPH is a genetic condition is a contested point with insufficient science to prove it either way. Researchers in South Africa conducted a retrospective pedigree and race-run data project looking at the genetic analysis of EIPH in Southern African thoroughbreds.5 They concluded that "epistaxis as associated with EIPH in the Southern African Thoroughbred has a strong genetic basis." They also recommended emphatically that "affected stallions and those racing while being treated with furosemide should be barred from breeding and not be considered as future sires."

Scientists, veterinarians and horsemen have not uniformly accepted this paper. Some question the methodology of this type of study and comment that such a broad and hardline conclusion based on only this one study is unwise. Rick Arthur, DVM, a member of the AAEP's racing panel, simply says, "There is legitimate suspicion that EIPH has a hereditary component, but nothing has been proven."

Genetically speaking, students of horseracing can point to Bartlett's Childers (Eclipse's great grandsire and a known bleeder), to Hero (one of the original three thoroughbred foundation sires and a known bleeder) and even to Northern Dancer (not an overt bleeder but one of the first horses to be treated with furosemide and one of the most prolific stallions in memory). If there was a hereditary component to EIPH and if these three prominent stallions carried and transmitted these genes, then EIPH cases should be increasing rapidly. While the prevalence of epistaxis has increased slightly over time, the rate does not approach what would be expected if so many prominent stallions were in fact passing on this condition. As Arthur explained, the best we have is a "legitimate suspicion," and the more correct conclusion is that more research and studies should be done focusing on this question.

Many in the horse industry suggest that perhaps the debate should be widened as well. Why single out furosemide, they say, when any number of orthopedic procedures done to straighten foals' legs or to correct various conformational defects (many with more proven genetic tendencies than EIPH) are not being discussed? Shouldn't these procedures—which are done worldwide—be considered when discussing the "weakening of the breed"? Focusing on furosemide, some say, seems to be a singular witch-hunt that avoids the larger issues of what is best for the horse and for the industry.

The United States Trotting Association (USTA) recently reviewed furosemide use and issued a position statement that covers the known information about EIPH and furosemide and addresses positions critical of its use. "Given the stress experienced by equine athletes during competition, EIPH is expected to occur in excess of 90 percent of all racehorses," the USTA said in a press release. "The use of furosemide has for quite some time been an accepted therapeutic resource for the horse industry in combating the effects of EIPH." These USTA comments nicely summarize what we know—horses bleed, furosemide works. Beyond this point, the debate continues. And science alone may not be enough to stem the controversy.

Dr. Kenneth Marcella is an equline practitioner in Canton, Ga.


Source: DVM360 MAGAZINE,
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