Equine facilities claim positive results with hyperbaric-oxygen therapy
As hyperbaric-oxygen therapy (HBOT) – the use of oxygen under pressure – gains wider acceptance in human medicine, its application in equine and small-animal veterinary medicine has been growing, too.
They are used in human medicine to help treat some diseases (with Medicare approval) and conditions such as acute carbon-monoxide poisoning, decompression illness, gas embolism, gas gangrene, progressive necrotizing infections and preservation of skin grafts. The list has become extensive.For horses, HBOT is used to assist healing and to speed recovery of poor-healing wounds, certain aerobic and anaerobic infections, bone (osteomyelitis) and necrotizing soft-tissue infections. It is also reportedly showing some benefit in patients with hypoxic-ischemic encephalopathy, tendinous and ligamentous injuries, respiratory conditions, as well as intestinal ischemic injury like colon torsion and small-intestinal strangulation.
In a hyperbaric oxygen chamber, horses breathe air at 2 to 3 atmospheres absolute, or about two to three times the normal environmental pressure at sea level.
Normal oxygen delivery to the tissues is dependent upon the proportion of O2 in the air, lung function, red-cell hemoglobin (Hb) and blood pressure.
Under normal circumstances, Hb is 97 percent saturated with oxygen, with a very small amount dissolved in the blood plasma.Via the mitochondrial oxygen-transport system, the partial pressure of oxygen is reduced in a cascade of succeeding decreases, ultimately delivering oxygen to tissues at a significant decrease in partial pressure as blood flow exits the lungs and progresses to the cells.
HBOT and wound healing
The failure of wound healing often is due to persistent infection, malperfusion and hypoxia, cellular failure, unrelieved pressure or recurrent trauma.
Hyperbaric oxygen therapy produces a directly proportional increase in the plasma volume fraction of transported oxygen and delivery to the injured tissues. With increased cellular and muscle pO2, the tissues become saturated with oxygen, assisting the healing process.
Hyperoxygenation allows for reversal of localized tissue hypoxia, which may be secondary to ischemia or other factors of the compromised, non-healing wound site. For the hypoxic wound, HBOT corrects the pathophysiology related to oxygen deficiency and impaired wound healing.
According to the Hyperbaric Oxygen Committee report in 2003, "a key factor in HBOT's enhancement of the hypoxic wound environment is its ability to establish adequate oxygen availability within the vascularized connective tissue compartment that surrounds the wound."
Neutrophils, fibroblasts, macrophages and osteoclasts all depend on an oxygen-sufficient environment to adequately promote healing. Proper wound healing is promoted with "improved leukocyte function of bacterial killing, antibiotic potentiation and enhanced collagen synthesis," which occurs during periods of increased tissue pO2.